الفهرس 
Review of literature
Histology of the prostateOnly 14 pages are availabe for public view
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Abstract
Prostatic carcinoma is a disease with increasing morbidity and mortality. It is the fourth most common male malignancy worldwide.
In Egypt during the years 1990 - 1997, cancer prostate constituted 0.03 % of cases that received by the Department of Pathology at National Cancer Institute. Although several genetically altered regions have been described in prostate carcinoma, the actual genes important for initiation and progression have not been clearly elucidated.
The DNA mismatch repair (MMR) system plays a critical role in maintaining genetic stability by recognition and processing mismatched nucleotides that may occur during DNA replication genetic recombination, and as a result of some types of physical or chemical damage to DNA.
The aim of this study was to evaluate the immunohistochemical expression of the DNA mismatch repair protein MSH2 in prostatic carcinoma cases and its correlation with available clinical data and histopathological findings important in the prognosis.
This study was carried out on sixty six cases, 24 NPH cases and 42 prostatic carcinoma cases. The studied cases were obtained from Pathology Department, Faculty of Medicine, Menoufyia University and Pathology Department, National Cancer Institute(NCI) Cairo University during the period between 1998 and 2003.
In prostatic adenocarcinoma cases, the ages ranged from 43 to 92 years with a mean j: SD of 68.71± 9.94 years. The clinical stage was available for 32/42 (76.2%) of the studied cases. According to TNM criteria 19 (59.4%) were T2, 11 (34.4%) were T3, and 2 (6.2%)