الفهرس 
Steroids oral contraceptivesOnly 14 pages are availabe for public view
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Abstract
The present study investigates the effects of low - dose pills on the hemostatic system by using newly developed marker of hemostatic activation, named prothrombin fragment 1 + 2.This work was conducted at Shibin El-Korn and Benha teaching Hospitals, during the period from October 1994 to March 1995. Fifty two healthy women were using low - dose pills for period more than two years and 30 healthy women were not use pill (control group). All of them fulfilled the selective criteria. All women were subjected for enough clinical history and complete examination. Plasma level of prothrombin fragment I + 2 was assayed using ELISA procedure. Serum glutamic oxaloacetic transaminase (GOT), alkaline phosphatase and total bilirubin levels were estimated, for mere to give an idea about their liver function to exclude the hepatic cause of hemostatic change and any women shown any abnormally high liver function parameter (s) was excluded from the study.
Our study showed
No statistically significant increases in plasma prothrombin fragment I + 2 level in pill users than that of non - users (control group) (P> 0.05).
There was statistically significant positive correlation (P < 0.01) between plasma prothrombin fragment 1 + 2 level and body weight of pill users (obese - pill users).
No statistically significant correlation between plasma prothrombin fragment 1 + 2 level and the duration of pill use, age, parity or the type of low-dose pills (P> 0.05).