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Abstract
Beta-thalassernias are the most important types of thalassemia because they are so common and produce severe anemia in their major forms. Patients with beta-thalassemia major are known to have dysfunctions of the renal, cardiopulmonary, reticuloendothelial, and other systems due to deposits of iron.
Repeated transfusions, which remain as standard treatment procedure to some of these conditions, generate a state of iron-
overloading that further accelerate production of reactive oxygen species (ROS) that tend to deplete cellular antioxidants.
Excess of tissue iron might be responsible for the increase in lipid peroxidation as demonstrated by the increase in plasma and urine malondialdehyde (MDA). Excess MDA further damaged the kidney cell resulting in tubular defects manifested by proteinuria, aminoaciduria,
* increased urinary levels of Beta2-microglobulin and N-acetyl-Beta-glucosaminidase (NAG).
The aim of the present study is to study the antioxidants status in thalassemic patients and the correlation of some antioxidants and serum ferritin level with renal function in thalassemic children.
The study was carried out upon 67 children in the age range 6-12years and of different sex groups, classified as follow:
Group(I): 44 children with Beta-thalassemia major.
Group(II): 23 children served as controls.