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العنوان
Pcr detection of minimal residual disease in pediatric acute lymphoblastic leukemia /
الناشر
2001.
المؤلف
Abu el-khar, Hesham abdel-Ghany.
هيئة الاعداد
باحث / Hesham Abd El- Ghany Abu El-Ghar
مشرف / Farida El-Rashidi
مناقش / Azza Tantawy,
مناقش / Alaa El-din El-Shafey
الموضوع
Hematopoietic stem cells- Transplantation.
عدد الصفحات
156 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب
تاريخ الإجازة
1/1/2001
مكان الإجازة
جامعة المنوفية - كلية الطب - Pediatrics
الفهرس
Only 14 pages are availabe for public view

from 188

from 188

Abstract

Acute lymphoblastic eukemia is the most common form of ignacy among pediatric age group, it is a heterogeneous ase with multi system effects.
Thirteen ALL patients were involved in this work. They
5 malses and 8 females with a mean age of 7.5 ± 4.07 years
peak incidence of 2-6 years in about 53% of cases.
Splenomegally was found in 10 cases, 76% Total leucocytic
amon our patients ranged from 2.8 — 251.2x 109/L with a
value of5l.530 ± 7.940 x i09/ L Platelet count with a range 15—485 x 109/L and a mean value of 96.230 ± 27.98 x 109/L
Hemoglobin level with a range of 4.6— 9.4 gm/dl and mean ucof 7.29 gm/dl± 1.38 gm/dl.
Inimunophenotyping analysis reveals 5 patients were T-cell
(38%) and 7 patients pre B-cell (53%) and one patient mature
(7.5%).
We
tested for immunogloblin heavy chain gene ,ments by polyrnerase chain reaction in peripheral blood
bone marrow of patients at diagnosis and after induction of
sio n.
At diagnosis peripheral blood testing revealed negative plification in one patient and postive amplification in twelve ients. One year follow tip revealed relapse in 6 patients and