الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Surgery and other major insults to the body (e.g., burns, infection, and
major trauma) elicit a profound neuroendocrine and cytokine response
collectively known as the “stress response”. The neuroendocrine element of
the stress response is activated by noxious afferent neuronal input and results
in activation of most major endocrine systems, including the hypothalamicopituitary,
adrenocortical, and renin–angiotensin systems.
Alpha-2 agonist administration in low concentrations as adjuvant during
the intraoperative period has resulted in a reduced requirement for other
anesthetic agents, fewer interventions to treat tachycardia, and a reduction
in the incidence of myocardial ischemia.
The aim of the study was to compare the effect of dexmedetomidine
versus fentanyl on the stress response of the body.
The study was carried out in Menoufiya University Hospital. Sixty
patients with ASA I or II physical status were scheduled for elective minor
procedures including, plastic, ear, or nose surgery. Their ages ranged from
21 to 45 years old.
Patients were divided the morning of surgery into three groups to receive
an IV infusion of dexmedetomidine, fentnyl or placebo starting 10 minutes
before the induction of anesthesia. They were divided into three groups
according to the drug infused: