الفهرس 
review of literatureOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus infection is a major cause of chronic liver disease world-wide (Alter et al., [989). The variable clinical presentation and genetic heterogeneity of HCV suggested that HCV have differecit genotypesHCV has been classified into six genotypes and a series of subtypes. The geographic epidemiology of HCV genotypes may provide information about transmission and. even clues to the viral origin. If different [-ICy types have different clinical pathological implication, knowledge of the I-ICV genotypes may have preventive and therapeutic implication.
The aim of this work was to study the current distribution of .HCV genotypes among Egyptian children with chronic liver disease and the possible relation between these HCV genotypes and the severity of liver disease.
This study was carried out on 83 children suffering from chronic liver disease, 49 of them were males and 34 were females with age ranged from 1.5 nonths to 1.5 years. They were selected from the pediatric outpatient clinic and inpatient department of Liver institute, Menoufiya University. Diagnosis of chronic liver disease was based on clinical,