الفهرس 
OxidationOnly 14 pages are availabe for public view
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Abstract
Enflurane, isoflurane and halothane release inorganic fluoride during their metabolic biodegradation in the body. Inorganic fluoride have been reported to cause renal insufficiency in man and experimental animals. Renal dysfunction produced is characterized by polyuria unresponsive to antidiuretic hormone and by variable effects on serum sodium, potassium, blood urea and serum creatinine as well as urinary osmolality and urinary excretion of sodium, potassium and oxalates. The onset and severity of the renal dysfunction are related to the plasma fluoride level, the extent of metabolism of the anaesthetic agent and it may be compromized by the superimposition of surgical stress, the presence of pre-existing renal disorder and the clinical requirements for the use of nephrotic adjuvant drugs (Bevan, Dudley and Horsey, 1973).