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Abstract The intact skin with lactic acid and fatty acids in sweat and sebacious secretions are unsuitable for living rnicroorganism~. In respiratory tract,organisms are trapped within the adhesive mucous of the mucous membranes and removed by ciliary movement, coughing and sneezing.Other barriers inchde washing action of tears, saliva and urine;bactericidal compounds, such as acid in gastric juice, sperrnine and zink in semen, lactoperoxidase in milk and lysozyme in tears, nasal secretions and saliva. Microbial antagonism associated with the normal bacterial flora of the body is an important barrier against pathogenic microbes (Roitt, 1994).The polymorph neutrophils form the dominant white blood cell in the blood stream. Their primary granules contain lysozyme,myeloperoxidase, and acid hydrolases. Their secondary specific granules contain lactoferrin as well as lysozyme,histaminase and transcobolamine 11. They are also a potent source of leukotrienes that constitute slow reacting substances (SRS). They also produce prostaglandins, e.g, PG E2 and platelet activating factor (PAF) (Reeves et al., 1991). |