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Abstract Colorectal cancer (CRC) is one the most common malignant neoplasms in Egypt . Adenomatous polyps and inflammatory bowel diseases (IBD) are considered the commonest pre - malignant lesions for CRC adipocytokines (Adiponectin , Resistin and Visfatin) are promising markers that may play a role in early detection of CRC . Aim of work : To assess levels of adiponectin Resistin and Visfatin in pre- malignant and malignant colorectal lesions |