الفهرس 
Overview on adipose tissueOnly 14 pages are availabe for public view
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Abstract
Adipose tissue is an anatomical term for loose connective tissue composed mainly of adipocytes, and classified in to WAT and BAT. Adipose tissue has an important endocrine function as it produces adipokines and inflammatory mediators as leptin, adiponectin, resistin, angiotensin, TNFα, IL-6 and PAI-1. Also adipose tissue is the greatest peripheral source of aromatase in both males and females contributing to the production of estradiol. The discovery of leptin marked major milestone in understanding the endocrinal role of adipose tissue. Leptin is an adipocyte-secreted hormone that informs the brain about the status of the body’s energy stores. In addition to its central function as a regulator of food intake and energy expenditure in hypothalamic nuclei, leptin is involved in many additional physiological processes. Adequate leptin levels are required to permit energy consuming processes such as reproduction, angiogenesis, wound healing, hematopoiesis, bone development and activation of the immune systems. Leptin resistance due to mutation of leptin or leptin receptor lead to obesity and insulin resistance. Leptin can be used as therapeutic target in treatment of obesity, congenital leptin defeciency and lipodystrophic leptin deficiency. Adiponectin is one of the most abundant adipokines produced by adipocytes. Adiponectin has attracted much attention because of its potential antidiabetic, antiatherogenic, and anti-inflammatory activities. Adiponectin is a potential considered as a plasma biomarker of metabolic syndrome and a possible therapeutic target for the treatment of type2 diabetes and cardiovascular disease.