الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Inflammatory bowel diseases (IBD) are those conditions characterized by a tendency for chronic or relapsing immune activation and /or inflammation within the gastrointestinal tract (GIT). Ulcerative colitis (UC) and Crohn’s disease (CD) represent the two major forms of IBD. Both forms of IBD are believed to result from the interaction of genetic, immune and environmental factors. IBD is suggested to be one of the most dramatic examples of redox imbalance or oxidative stress. Conventional drugs used in treatment of IBD include; aminosalicylates, glucocorticoids, antimicrobials, purine analogs, methotrexate and other immune modulators and infliximab. This study was carried out to evaluate the potential anti-inflammatory and antioxidant effects of fluvastatin and celecoxib in comparison with 5-aminosalicylic acid on acetic acid induced experimental colitis in rats.. Eighty healthy Sprague -dawley rats of both sexes, weighing 250+30gm were randomly divided into 2 major groups, as follows: Group A: Normal control group, (n=10) which received 0.5 ml of normal saline and Group B: Acetic acid induced colitis groups, (n=70). Induction of experimental colitis was by intracolonic administration of acetic acid 8% through an anal catheter. Then, rats in this group were randomly divided into 7 equal sub-groups each containing 10 rats, as follows; subgroup B1 that received 0.5 ml of normal saline and served as model control group, subgroup B2 which received 5-ASA 100 mg/kg/day, Subgroup B3 which received fluvastatin 6.25 mg/kg/day, subgroup B4 which received celecoxib 10 mg/kg/day , subgroup B5 which received combination of fluvastatin with 5-ASA in the above mentioned doses, Subgroup B6 which received combination of celecoxib and 5-ASA in the above mentioned doses and subgroup B7 which received combination of fluvastatin with celecoxib in the above mentioned doses. Saline, 5-ASA, fluvastatin and celecoxib were given by oral gavage once daily 24 hours after induction of colitis and for further 7 days. At the beginning (day 0) and at the last day of the study (day 8), rats in each group were weighed. On day 8, animals were sacrified by decapitation and rat colons were excised. A part from each rat colon was preserved in formalin 10% then the histopathological score (HS) was evaluated. Another part from each rat colon mucosa was sampled for determination of malondialdehyde (MDA), nitric oxide (NO) and reduced glutathione (GSH). Drugs used in this study played various degrees of treatment of experimental colitis as they decreased weight loss, which was markedly increased in this model. They, also, reduced nitric oxide and malondialdehyde levels, that were elevated in this model. Moreover, they increased reduced glutathione level, which was markedly decreased in this model and decreased the histopathological score, which was markedly increased in this model. Uses of combinations of these drugs were better than using them as monotherapy.