الفهرس 
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Abstract
The purpose of this study was to examine the expression of CD20 and CD27 in peripheral blood of rheumatoid arthritis patients compared to healthy control subjects. Immunological assessments included Red Blood Cells count, total leukocyte count, lymphocyte subpopulation counts, platelet count, hemoglobin and hematocrit counts. B- Cell subsets were examined with flow cytometry in the peripheral blood of patients with rheumatoid arthritis (RA) in comparison with healthy controls, their association with disease duration, activity and autoantibodies was investigated in order to reveal potential imprints of antigen-specific immune response in RA. Red Blood Cells, lymphocyte, platelets counts, hemoglobin and hematocrit were significantly different among the groups (data not shown). Total leukocyte was not significantly different among the groups. Among B-cell subsets, there was slight increase in CD20+ B cells in the groups of rheumatoid arthritis patients, but the difference between these groups statically not significant. Also, CD27+ B cell significantly increased in high active rheumatoid arthritis group and total rheumatoid arthritis group compared to that of age -matched control subjects group. The level of CD27+ B cell non significant increased in high active rheumatoid arthritis group when compared to low active rheumatoid arthritis group, While there was significant increased different for the level of CD27+ B cell in high active RA When compared to in remission RA patients (p=0.038). In addition, strong correlation was demonstrated between disease duration and the percentage of memory CD27+B cells in all rheumatoid arthritis patients groups (p < 0.0001). These results suggest that CD27 level can be used as diagnosis marker for rheumatoid arthritis patients not only but also used in follow up the patients during their treatment period.