الفهرس 
HISTORICAL REVIEWOnly 14 pages are availabe for public view
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Abstract
The first human cardiac allotransplantation came after about decades of serious eHperimental works which started by the work of Carrel and Guthrie at the begining of this The immunological barrier and tissue rejection were a major factors. Understanding the histocompatibility antigens HLA systems) and their role in tissue rejection was a contributing to the clinical application of organ The introduction of immunosuppressive drugs jastly cyclosporine led to control of the rejection process and by methothotrexate, azathioprin~, carticosteroids and of the graft suruival. However these drugs ar~ associated with innumerable side effects. Cyclosporine is the most and specific agent. However, a major obstacle to wide-spread use of cardiac transplantation and expanded selection for recipients is the inability to specifically suppress graft rejection. Cardiac transplantation is now considered as an established therapeutic modality fo~ selected patients with end-stage cardiac Most potential candidates have either coronary artery disease or cardiomyopathy- Caronary artery disease was the primary indication, but with time there was a progressive increase in the percentage of patients with cardiomyopathy. At