الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Inflammatory bowel disease (IBD) is an idiopathic disease, The two major types of IBD are ulcerative colitis (UC) and Crohn’s disease (CD), which are chronic inflammatory diseases of the gastrointestinal tract. As the name suggests, Ulcerative colitis is limited to the colon; Crohn’s disease can involve any segment of the gastrointestinal tract from the mouth to the anus. The incidence and prevalence of (IBD) have shown a dramatic increase in last decades. Increasing attention has given to the role of reactive oxygen metabolites in the pathogenesis of inflammatory bowel disease It has been proposed that, inflammation of mucosa causes impairment of antioxidant defense mechanism, and makes tissue more susceptible to oxidative damage increased oxidative stress and decreased antioxidant defenses in colonic mucosal biopsies of patients with inflammatory bowel disease. Also oxidative stress and reactive oxygen species (ROS) play an important role in tumor progression and ulcerative colitis associated carcinogenesis through lipid peroxidation and DNA damage resulting in transforming, accumulating mutations, and genetic instability. In addition to these chemical effects on the DNA molecule, recent studies have shown that regarding their role as second messengers, ROS also have complex signaling effects on tumor growth, cellular survival, and metastasis formation. Also we are in need for studies on the value of use of antioxidants in patients with active IBD.