الفهرس 
General introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Oxidative damage and immune system alteration induced by Cigarette smoking in Egyptian smokers was investigated in the present work.The present study was assessed on 30 smokers and 10 non-smokers. The smokers were classified according to smoking index equation. Cigarette Smoking caused:-Decreased lymphocytes count and lymphocyte proliferation response to PHA.- Increased neutrophils count and phagocytic activity.-Decreased serum total IgG level and Increased serum C3 level-Increased serum total cholesterol and serum total triglycrides concentrations.-Decreased serum high density lipoprotein (HDL) concentrations.-Increased serum low density lipoprotein (LDL) and serum very low density lipoprotein (vLDL).-Increased RBCs lipid oeroxidation product (MDA) level.-Decreased RBCs glutation (GSH) level and RBCs glutathione-S-transferase (GST) activity.-Decreased RBCs Super oxide dismutase (SOD) and Catalase (CAT) activities.-Increased serum alanine amino transferase (ALT) and aspartare amino transferase (AST) activities.-Increased serum lactate dehydrogenase (LDH) activity.-Increased serum creatine kinase CK activity in group A.-Increased serum C reactive protein (CRP) level.-No DNA fragmentation isolated from whole blood.- Upregulation in the expression of HSP 70kDa. cigarette smoking has a harmful impact represented in the induction of inflammatory and oxidative stress markers and suppressing both cellular and humoral immunity.