الفهرس 
Histopathological Study of Ovarian TumorsOnly 14 pages are availabe for public view
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Abstract
Ovarian cancer is one of the causes of female morbidity and mortality worldwide. In Egypt, ovarian malignancy accounts for 4% of over all malignancies among females.
A heterogeneous group of neoplasms arise in the ovary with a great morphologic diversity causing problems in diagnosis. Thus immunohistochemistry has become an important tool in the in the diagnosis of the main categories of ovarian tumors.
This study was conducted on 93 cases of ovarian neoplasms collected from archives of pathology department- faculty of medicine-Mansoura University. The cases underwent microscopic examination for proper histopathologic typing according to WHO classification in 2003. Proper grading and staging were performed. Immunohistochemical staining for WT-1, inhibin-α, calretinin, cytokeratins 7 and 20 was done, and their staining results were interpreted to asses their role in ovarian tumor diagnosis.
In this study, surface epithelial tumors were the commonest; comprising 44.1% of cases of which serous neoplasms were the most frequent (53.7%). The least frequent group was the mixed germ cell-sex cord tumors (11.8% and 2.2% of cases respectively).
Patients’ ages ranged from 9 to 79 years. Most ovarian tumors (48.4%) occurred in women between 41-60 years. Whilst, the least frequency of ovarian tumors is below 20 years of age (8.6%), in which germ cell tumors were the commonest.
Bilaterality was observed in surface epithelial tumors and metastatic tumors. More than 53% of surface epithelial tumors were unilateral and about 46% are bilateral. The reverse was true for metastatic tumors where 60% are bilateral and 40% are unilateral.
Immunohistochemical expression of WT-1 gene was demonstrated in 90% of malignant serous ovarian tumors in contrast to its negativity in other subtypes of ovarian carcinomas and metastatic tumors. Calretinin has been shown to be a slightly more sensitive marker but less specific than inhibin-α as a marker of sex cord-stromal tumors.
All primary ovarian surface epithelial tumors (97.6%) and 46.6% of metastatic tumors exhibited cytoplasmic CK7 expression. However, cytoplasmic expression of cytokeratin 20 was limited to 7.3% of primary ovarian surface epithelial tumors and 33.3% of metastatic tumors most of which were of colonic origin.