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العنوان
Phytochemical investigation of some plants belonging to families Apiaceae and Cucurbitaceae /
المؤلف
Sallam, Amal Ahmed Attwa.
هيئة الاعداد
باحث / أمل أحمد عطوه سلام
مشرف / السيد شاكر أحمد منصور
مشرف / كويتشى كاتيا
مشرف / عطا الله فؤاد أحمد
مناقش / سحر رفعت جدارة
الموضوع
Daucus glaber. Apiaceae.
تاريخ النشر
2009.
عدد الصفحات
468 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
01/01/2009
مكان الإجازة
جامعة المنصورة - كلية الصيدلة - Department of Pharmacognosy
الفهرس
Only 14 pages are availabe for public view

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Abstract

This thesis includes 2 parts: Part I: Phytochemical investigation of the aerial parts of Daucus glaber (Forssk.) Thell. herb belonging to F. Apiaceae. <It includes: 1-The isolation and structural elucidation of a series of new sesquiterpene lactone esters of the guaiane-type named Daucoguaianolide A, B, C, D, E and F, a new sesquiterpene lactone ester of the eudesmane-type named Daucoeudesmanolide A
2-This is the first report for the presence of sesquiterpene lactones within the genus Daucus.
3-The isolation and structural elucidation of a series of new phenylpropanoid esters named Glaberins A, B, C, D and E.
4-This is the first study that establish the relative stereochemistry of a phenylpropanoid ester using X-ray diffraction analysis and the absolute strereochemistry using modified Mosher’s method after chemical modification.
5-Some of the isolated compounds were tested for their cytotoxicity against P-388 murine lymphocytic leukemia cells showing moderate and weak activities. Part II: Phytochemical investigation of the roots of Bryonia cretica L. F. Cucurbitaceae.
1-The isolation and structural elucidation of a new cucurbitane-type triterpene glycoside that was named Bryocreticoside A,2 new isocucurbitacins named isocucurbitacin G and isocucurbitacin H, in addition to the known cucurbitacins G, H, J and isocucurbitacin D.
2-The relative stereochemistry at C-24 was established in the epimers; isocucurbitacin G, H depending on the X-ray diffraction analysis and a correlation between the results of the X-ray diffraction analysis and the 1H and 13C NMR results for the isolated cucurbitacin epimers was established.