الفهرس 
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Abstract
Lymphomas are a heterogeneous group of malignancies of B cells or T cells that usually originate in the lymph nodes in any organ of the body. The two broad categories of lymphoma, Hodgkin’s disease and non-Hodgkin’s lymphoma (NHL) have such different clinical manifestation and treatments that they are considered separately. E-cadherin is glycoprotein expressed predominantly on the surface of epithelial tissues, where it plays a major role in the establishment and maintainance of normal tissue architecture and connect cells to each other. So, this study was designed to 24 patients with newly diagnosed NHL. 12 patients with newly diagnosed HD and 8 healthy controls. They were selected from Hematology Oncology Unit Mansoura University Children Hospital. All patients (at diagnosis) and healthy controls were subjected to some laboratory investigations as CBC, serum cratinine, uric acid, serum LDH, Liver function tests (ALT, AST, Alnumin and Bilirubin). Serum levels of E-cadherin using ELISA technique were carried out for patients (at diagnosis) and healthy controls. Our studies showed that E-cadherin levels were significantly elevated in patients with HD and NHL compared to control group. Also, there was serum E-cadherin levels that showed statistically significant increase in advanced stages in HD and NHL. There was no correlation between E-cadherin levels and different pathological grades in HD, while in NHL there was a significant elevation of E-cadherin level in patients with high grade lymphoma compared to low grade lymphoma.