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Abstract
Patients with end-stage renal disease undergoing HD are exposed to oxidative stress. Increased levels of MDA and 4-HNE were found in plasma of uremic patients indicating accelerated lipid peroxidation (LPO) as a consequence of multiple pathogenetic factors, those highly reactive metabolites are able to bind to protein, Nucleic acids, and other molecules are able to exacerbate tissue and organ damage, e.g. cardiotoxic effect.
Renal anaemia was shown to promote oxidative stress. Cardiovascular injury has be shown to be the most critical factor affecting quality of life and mortality in patients with CRF. Oxidative stress has be thought to be an important risk factor for cardiovascular disorder.
The work was done to evaluate the level of LPO products (MDA and HNE) in patients with CRF before and after dialysis in relation to Hb level, and lastly in relation to LVH. This study has been conducted on 20 children (8 males and 12 females) suffering from CRF before dialysis (GFR = 10 -30 cc/min/1.73 m2) and 20 children (8 males and 12 females) suffering from CRF after dialysis and EPO therapy for at least 6 months. They were selected from those uremic children attending Haemodilaysis units of Zagazig university hospital as well as Ain shams university Hospital, their age ranged from 4 to 16 years.