الفهرس 
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Abstract
Present work aimed mainly to study the biochemical effects of some antilipolytic drugs mainly Nicotinic acid, Acipimox and Gemfibrozil on certain aspects of carbohydrate and lipid metabolism in normal and STZ diabetic rats.
Induction of diabetes was done through I.P administration of STZ (35 mg /kg body weight).
Experimental Design:
Normal and diabetic animals were divided into three main groups (A, B, C). Each was further subdivided into four subgroups, (10 animals per each). Normal and diabetic animals were directed to the following classification: Group A: Animals received the drugs under study daily for 30days.
Subgroup 1 : Rats received no drugs and served as control.
Subgroup 2 : Rats received Nicotinic acid (42.8 mg/kg/day orally).
Subgroup 3 : Rats received Acipimox ( 17.14 mg/kg/day orally).
Subgroup 4 : Rats received Gemfibrozil ( 17.14 mg/kg/day orally .Group B: Animals received the above mentioned drugs for 45 days using the same doses, classification as mentioned in groupA.
Group C: Similar classification, doses and extended for 60 days.
At the end of each experimental period blood was collected and directed for determination of glycated hemoglobin, glucose, triacylglycerol, non-esterified fatty acids (NEFA), lipase activity and insulin level. Animals were decapitated after 8 weeks treatment, liver and adipose tissue samples were prepared and processed instantly for determination of Triacylglycerol, NEFA and liver glycogen content.
Results: -
STZ diabetic rats demonstrated: 1- In blood: higher levels of plasma glucose, triacylglycerol, NEFA, lipase activity and blood glycated hemoglobin, however, insulin showed significant decrease