Search In this Thesis
   Search In this Thesis  
العنوان
Studies on the Effect of certain Additives on the Antimicrobial Activity of Some Non Absorbable Oral Antibiotices /
المؤلف
Abdel Rahman, Wafaa Mahfouz Mahmoud.
هيئة الاعداد
باحث / وفاء محفوظ عبدالرحمن
مشرف / عفاف ابوالخير
مشرف / حمدالله حافظ زيدان
مشرف / محمد سلامه محمد
الموضوع
Streptomycin. Polymyxin.
تاريخ النشر
1981.
عدد الصفحات
129 p.:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات
تاريخ الإجازة
1/1/1981
مكان الإجازة
جامعة الزقازيق - كــليـــة الصيدلــــة - ميكروبيولوجيا
الفهرس
Only 14 pages are availabe for public view

from 153

from 153

Abstract

The effect of a total of 23 pharmaceutical materials - commenly Co-administered with antibiotics- on the antimicrobial activity of some non abgorbable antibiotics, namely, streptomycin, neomycin, kanamycin, polymyxin 3 and nystatin was studied. The materials used included the antacids, magnesium trisilicate and aluminum hydroxide; the demulcents, methyl cellulose, sodium carboxymethyl cellulose and carbowaxes 4000 and 6000, the gastric protective and adsorbent materials, kaolin and pectin; the laxative, agar J and the suspen¬ding agents, sodium alginate, carbopol 934 and bentonite ; as well as many others such as ferrrous sulfate and cupper sulfate; vitamins, B1, and B6 ; the eudrigits ( RS100 , RSPM, RL100 RLPM and S90 ) and polyvinyl pyrrolidone,
The results obtained showed a good correlation between the dose-response curves, the MIC and MBC of each antibiotic ( in absence and in the presence of various materials ) on one side and the actual percentage of activity observed after incubation of the antibiotic with each, of those materials on the other side.