Search In this Thesis
   Search In this Thesis  
العنوان
Synthesis and elucidation of certain heterocyclic nitrogenous bases of chemotherapeutic interest /
المؤلف
Yousif, Mamoun Yousif.
هيئة الاعداد
باحث / مؤمن يوسف يوسف
مشرف / أ. أ. أبو عوف
مشرف / م. الكرداوى
مناقش / أ. أ. أبو عوف
الموضوع
Pharmaceutical chemistry. Nitrogenous. Chemotherapeutic.
تاريخ النشر
1981.
عدد الصفحات
143 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
01/01/1981
مكان الإجازة
جامعة المنصورة - كلية الصيدلة - Department of pharmaceutical chemistry
الفهرس
Only 14 pages are availabe for public view

from 179

from 179

Abstract

Considering the several theories and suggestions enlightened the mechanism of action of a manifold number of hydrazine compounds, certain derivatives of them showed antimicrobial activity and in particular antitubercular or antiamaebic potency. Isoniazid, p-aminosalicylic acid hydr-azide, 2-furoyl hydrazine, 2-thenoyl hydrazine, and certain B-pyrone and b-pyridone carboxylic acid hydrazides are the most promising antitubercular hydrazine derivatives; while p-hydroxybenzoicacld-(5-nitrofurfurylidene)hydrazide,1,1-(phenylenedimethylene)dihydrazine and certain quinoline carboxylic acid hydrazides showed antiamaebic activity. On this basis the b’-pyridone ring was adopted to obtain new series of arylidene or acyl derivatives of l-(p~hydrox-yphenyDchelidamic acid dihydrazide.