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العنوان
Synthesis of certain substituted aminocresols likely to possess antiparasitic activity /
المؤلف
Eisa, Hassan Mohamed Hassan.
هيئة الاعداد
باحث / حسن محمد حسن عيسى
مشرف / عبدالمل عبدالرحمن أبو عوف
مشرف / محمد محمود الكرداوي
مناقش / أ. رجب
الموضوع
Organic chemistry. Antiparasitic activity.
تاريخ النشر
1978.
عدد الصفحات
135 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات (المتنوعة)
تاريخ الإجازة
1/1/1978
مكان الإجازة
جامعة المنصورة - كلية الصيدلة - Department of pharmaceutical organic chemistry
الفهرس
Only 14 pages are availabe for public view

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from 157

Abstract

Certain benzylidene,substituted benzylidene and cinnamylideneamino compounds were prepared in 1969 and proved to possess both antimalarial and antibacterial activities.pointing out this fact,the synthesis of a new series of schiff’s bases was inspired using the already active 4-amino-∞-piperidino,merpholino,or piperazino-o-cresols,as parent compounds.certain∞-dialkylamino-o-cresols were recognised as good antimalarials.when the active moiety of such molecules i.e. the 3-dialkylaminomethyl-4-hydroxyaniline residue was attached to 7-chloroquinoline or chloromethoxyacridine gave amodiaquine and quinacrine analogue respectively which proved to be potent antimalarials.
Accordingly, the synthesis of several chains derived from the rules Chef used Krbzolat the secretary, which proved its effectiveness in this field as a preliminary measure material interaction. It was also noted that some Alakilat bilateral Kizulat secretary have strong effect in genocide Blasmodia Malaya like Alamkudiaakin and similar Alkwynachrin, and on this basis has been the integration of effective portion in these vehicles: the bilateral AKEL amino phenyl-4 - hydroxy-aniline in a molecule Withalimid or one Similarities to produce compounds close likeness of Mrbakat the Alnaftukenon, which proved to be effective in the treatment of Malaya and the hope of reaching vehicles with greater efficiency and less toxicity.
This message includes the preparation of eight thirty Makhlqa the new deadline is not mentioned in the references traded. Has been the preparation of these new vehicles through several Chemical reactions are summarized as follows:
1) the interaction of Vehicle prepared Alamaimih (4 - Amino - alpha - Bbreden or Morvolin or Berazin - Ortho - Krizwol) with some aromatic Alaldhedrat the different and resulted in a series of derivatives of the chef.
2) the synthesis of a series of derivatives Almanej through the interaction of n (3 - vinyl Khidroxy) Alwithalmad or Alnvathalimid with some amines and formaldehyde Mahlho.
It was found that the composite output from the interaction of n - methyl Berazi-Naw Pirollan has given an oily substance and therefore necessitated special treatment to get them in the form of amorphous.