الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Leukemias are a group of disorders characterized by the accumulation of malignant white cells in the bone marrow and blood. These abnormal cells cause symptoms because of bone marrow failure and infiltration of organs. E-Cadherin is glycoprotein expressed predominantly on the surface of epithelial tissues, where it plays a major role in the establishment and maintains of normal tissue architecture and connect cell to each other. E-Cadherin level was elevated in serum of acute leukemic patients, leading to increase invasion and metastasis of cancer where E-Cadherin consider as tumor suppressor molecule in normal levels. In this study, laboratory data were done including CBC, liver functions, kidney function and bone marrow aspiration. Also immunophenotyping was done for acute lymphoblastic leukemia (CD3, CD10, CD34, and HLA-DR) and for acute myeloid leukemia (CD34, CD56, HLA-DR). Also, assessment of E-Cadherin level using Elisa method was performed for patients with newly diagnosed acute leukemia and after treatment. It can be concluded, that increase level of E-cadherin in acute leukemia is one of the reasons leading to treatment failure. So, the determination of the E-cadherin level was considerable a powerful predictor of clinical outcome of acute leukemia.