الفهرس | Only 14 pages are availabe for public view |
Abstract Stem cells are defined as undifferentiated cells that possess two properties: Unlimited self renewal and Potency. They are differentiated according to their potency into totipotent stem cells, pluripotent stem cells, multipotent stem cells and unipotent stem cells. According to the source: Embryonic stem (ES) cells and Adult stem cells. Embryonic stem cells are derived from the inner cell mass of blastocyst- stage embryos generated in in vitro fertilization laboratories. All other stem cells are referred to as Adult stem cells, regardless the age from which the cells were derived as bone marrow derived stem cells. Stem cells can change their appearance and assume characteristics that resemble those of other tissue cells, this is known as plasticity. There are at least four postulated mechanisms: Transdifferentiation, cell fusion, bystander effect, and de-differentiation/ re-differentiation. There are three broad groups of liver disease can be identified for the purpose of cell therapeutic options: acute liver failure, inherited metabolic liver diseases and end-stage liver disease (cirrhosis). The conditions and requirements of cell therapy differ for each of these classes. |