الفهرس 
Introudaction and aim of workOnly 14 pages are availabe for public view
 |  | from | 180 |  |  |
| | | from | 180 | | |
Abstract
Breast cancer is one of the commonest cancers in female. About one of every ten women will have breast cancer during her life time. This study was done on 100 patients with invasive breast cancer, who attended Mansoura Clinical Oncology and Nuclear Medicine Department in the period from December, 2002 to November, 2006. 46 of Patients were L.N negative and 44 patients were L.N positive. In addition to 10 metastatic cases who received Trastuzumab as a part of their first line therapy. The aim of this study was to investigate the prognostic & predictive values of MMP-2 and HER-2/neu over expression in breast cancer, To study their association with breast cancer, identify patients with worse prognosis within groups of a general favorable prognosis e.g. node negative patients, to evaluate the results of novel Trastuzumab therapy directed against HER-2/neu protein. The study showed that MMP-2 & Her-2/neu were strong prognostic factors for D.F.S and O.A.S in breast cancer, their expression predicted poorer outcome in breast cancer patients. Trastuzumab showed higher efficacy than chemotherapy alone as a first line therapy in metastatic breast cancer.