الفهرس | Only 14 pages are availabe for public view |
Abstract This study was carried out in Clinical Pathology Departement and Mansoura University Children Hospital(MUCH) .Pediatric patients were referred from outpatient clinic and from other departments of MUCH to Haematology Departement of the same hospital .They were complaining of bleeding manifestations like prolonged bleeding after injuries, following tooth extraction, circumcision and following trauma. Also patients presented with epistaxis, gum bleeding, ecchymoses and haemartherosis. A total of 105 pediatrtc patients were referred to MUCH. They were divided into 2 groups ; 1. Pediatric patients with congenital coagulation disorders. They were 75 patients (45 cases with haemophilia A ,15 cases with haemophilia B , 5 cases with VWD, 2 cases with factor X deficiency,2 cases with factor V deficiency, 2 cases with factor X1deficiency and 4 cases with factor XIII deficiency). Their mean age was 45.36±48.59 months. 2. Pediatric patients with acquired coagulation disorders .They were 30 patient (15 cases with liver disease , 10 cases with haemorrhagic disease of the neoborn and 5 cases with DIC). Their mean age was 56.13±61.61 months. - Haemophilias are the most prevalent congenital coagulation disorders among children attending MUCH. - Factor VIII C / VWF Ag ratio is a useful marker for detection of carriers in haemophilia families. - Inhibitors to VIII and IX do exist in a significant fraction in haemophilic patients treated with factor concentrate. - Liver disease is the most common aquired coagulation disorders among children attending MUCH. |