الفهرس 
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Abstract
Nonalcoholic steatohepatitis (NASH) can vary from mild hepatic inflammation and steatosis to cirrhosis. It is most frequently associated with obesity, Type 2 diabetes mellitus, hyperlipidemia. The prevalence of fatty liver and NASH in the general population is 20% and 3%, respectively. Cytokines ultimately control the pathophysiology and progression of liver diseases. TGFgbs1 has a dominant role in mediating hepatic fibrosis. Rationale: We investigated the role of serum TGFbeta1 concentration in the progression of different stages of non alcoholic fatty liver diseases (NAFLD) . Patients & Methods: Seventy eight patients with NAFLD were evaluated, 45 female and 33 male. They were divided into 4 groups; simple steatosis, NASH, cirrhosis and hepatoma. Serum obtained from patients was used to detect TGFbeta1 concentrations by an ELISA method. Results: TGFgbs1 serum level was higher in NAFLD cases when compared to the normal control. TGFgbs1 of the NASH group was found to be the highest when compared to cirrhosis and Hepatoma groups. It was higher in hepatoma cases more than those of the cirrhosis ones. In conclusion; TGFgbs1 was significantly higher in the severe forms of steatosis (NASH, cirrhosis & Hepatoma) versus simple steatosis suggesting its role in the progression of NAFLDs.