الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
The present study is designed to measure circulating IGF1 and IGFBP3 concentrations in elderly patients with D.M. The results will be compared with those in non diabetic age, sex and body weight matched controls. This may provide important clues to understand the presence of age related hyperglycemia.This study investigated 25 elderly type 2 diabetic patients with age range from 60 to 76 years. . In addition the study included 39 middle aged diabetics (diseased control group) with ages range from 45 to 59 years. In addition 10 clinically normal healthy subjects of matched age and sex were also included representing the control group with ages range from 50 to 65 years. Results showed that the circulating IGF1 mean value was significantly decreased in the studied elderly subgroups (diabetic, diabetic hypertensive and diabetic hypertensive with IHD subgroups ) aged more than 60 years in comparison to non diabetic control group. The mean level of IGFBP3 was lower in the studied elderly subgroups (diabetic, diabetic hypertensive and diabetic hypertensive with IHD subgroups) in comparison to non diabetic control. serum levels of IGF1, in females (diabetic, diabetic hypertensive and diabetic hypertensive group with IHD groups) were significantly lower than in males within the corresponding group. At the same time, serum levels of IGFBP3 were higher in females than males. serum mean level of IGF1 was lower in elderly diabetic hypertensive subgroup in comparison to elderly diabetic subgroup. it has been found that there were decline of both IGF1 and IGFBP3 concentrations with aging. In the present work, serum mean level of IGF1 in middle aged diabetic subgroup (< 60 years old) was lower than non diabetic control group but the difference did not reach significance. The serum mean values of IGFBP3 were significantly decreased in all middle aged studied subgroups (diabetic, diabetic hypertensive and diabetic hypertensive with IHD subgroups) in comparison to its level in non diabetic control group.The study revealed that IGF1 and IGFBP3 are age related as there was decline in their levels in diabetics with aging.