الفهرس 
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Abstract
he connections between the two diseases have been researched from a variety of aspects as: the respiratory tract anatomy and physiology, epidemiological aspects, pathophysiological point of view, along with the theories that have been proposed to explain how these structures interact. sICAM1 is one of adhesion molecules suggested to participate in the pathophysiology of developing allergy of the respiratory tract by many mechanisms. Aim of work: This work was designed to study locally expressed sICAM1, IgE level, MDA level and eosinophil count in respiratory tract allergies namely bronchial asthma and allergic rhinitis , their biochemical significance and the implication of the variation of their levels on the pathophysiology of asthma and rhinitis. Subjects and methods: The study was carried out on 30 subjects. They were divided into three groups: a group of 9 patients suffering from bronchial asthma, another group of 9 patients suffering from AR and finally 12 apparently healthy volunteers as a control group. The samples were assayed for sICAM1, IgE by enzyme linked immunesorbent assay (ELISA), MDA by colorimetric method and differential cell count to determine eosinophil count using Leishmann and Hansel stains. Results and Conclusion: sICAM1, IgE and eosinophil count are increased significantly in local secretions (sputum and nasal secretions) of both asthma and allergic rhinitis pointing to their important role in the development of airway allergy . MDA level in local secretions of both asthmatics and rhinitic patients are elevated considerably suggesting the role of oxidative stress in the dramatic events of airway allergy and airway remodeling. sICAM1 level in sputum and MDA level in nasal secretions may be considered as good markers for airway allergy. Accordingly, secretion analysis ,in particular sputum and nasal secretions, could be used as a non invasive tool in the assessment of respiratory allergy. Also, according to our findings regarding the significant correlation of the former mentioned markers between them in the nasal and bronchial secretions of asthma and rhinitis we can support suggestions that allergic rhinitis and asthma are two clinical manifestations of a single disorder of the airways