الفهرس 
Introduction
Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Apoptosis is a physiologic form of cell death. It appears to be implicated in the regulation of the number of cells in various tissues. Apoptosis occurs during development, in response to certain physiologic stimuli, and secondary to cell injury and stress.Activation of apoptosis plays a major role in virtually all phases of mammary gland development and remodeling. Integrity of the secretory epithelium during lactation depends on a balance of survival and death signals which regulate programmed cell death. This process also occurs spontaneously in neoplastic breast tissue. Conclusion : Apoptosis increases gradually during the development of breast carcinoma i.e., from normal epithelium to fibroadenoma to duct carcinoma insitu to invasive carcinoma and was correlated positively to the grade of carcinoma. Positive p53 was used as a marker for apoptosis while negative bcl2 was used as a marker for apoptosis. In breast carcinoma, bcl2 and p53 were linked to the apoptotic pathway. These oncoproteins have a significant role in prognosis of breast carcinoma patients and may even be parameters, which influence therapeutic strategies and bcl2 may be more an indicator of therapeutic response than a prognostic factor. Moreover, it appears that bcl2 and p53 expressions are associated with prognostic histopathological features. Accordingly, bcl2 and p53 immunohistochemical expressions should be evaluated prospectively to determine their values in predicting the clinical course of breast carcinoma. Additional larger studies will help to further clarify the contribution of bcl2 and p53 to the biological and clinical behaviour of breast carcinoma, and since apoptotic cells can be counted with good reducibility in H&Estained tumour sections, the AI may be used as an additional prognostic indicator in invasive breast cancer. This study also, provide some support for a role of bcl2 in mammary gland apoptosis during involution. The association between bcl 2 and p53 expression and the pathogenesis of fibroadenosis and fibroadenoma is not clear and need further investigations.