الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study is a prospective cross sectional field study that was planned to determine the seroprevalence of maternally acquired measles, mumps and rubella IgG antibodies in Egyptian infants for optimum timing of vaccination. A total number of 267 infants of different ages were included from urban and rural health care centers of Mansoura, Meet Ghamer, and Belkas centers, Dakahlia Governorate. After full history and clinical examination, sterile blood samples were taken from these infants and serum was separated and stored at 70 C for assay of IgG antibodies by ELISA technique. Stastistical analysis of the results showed that the seroprevalence of IgG antibodies at 2 months of age was 70.2%, 71.9% and 82.5 for measles, mumps and rubella respectively and declined to the nadir at 6 months. In addition, there was a significant difference between the median levels of IgG antibodies at different ages. Urban infants had a significantly higher IgG antibody levels compared to rural infants . Infants with history of maternal infection of measles and mumps had significantly higher IgG antibody levels compared to those with negative history. There were no significant differences between different socioeconomic standards, infants of different birth orders or infants with different maternal ages. The seroprevalence was not affected by the mode of delivery or history of maternal illnesses. Conclusions: Maternally acquired measles, mumps and rubella IgG antibodies decline gradually after birth to reach the nadir at 6 months with slight increase thereafter. Urban infants had significantly higher IgG antibody levels than rural infants and so did infants with history of maternal infections. Transplacental IgG antibody levels did not differ with socioeconomic standards, maternal age, mode of delivery or maternal illness.