الفهرس | Only 14 pages are availabe for public view |
Abstract Postrenal transplant lymphoproliferative disorders (PTLDs) is a well known category among all the other lymphoproliferative disorders. The cause of this complication is mainly due to long term immunosuppression, and infection particularly by EpsteinBarr virus (EBV). Early recognition of clonal changes is very important for early therapeutic intervention as most of these changes are polyclonal. Yet the transition to oligo and subsequent monoclonal is important for follow up with other investigations to reach the proper diagnosis. So, the objective of this study was to clarify whether postrenal transplant lymphoproliferative disorders are polyclonal (benign), or monoclonal (malignant) Bcell proliferation. The statistical analysis of our results showed the following: 1 There is a high statistically significant increase in CD19 in patients when compared to the healthy group. 2 There is a high statistically significant increase in CD20 in patients when compared to the healthy group. 3 There is a statistically significant difference in Kappa/Lambda ratio in patients when compared to both the healthy group and the lymphoma patients. And we concluded that some of these post renal transplant patients had abnormal hematological findings in the form of oligoclonality, which may lead to subsequent hematological malignancies; PTLDs. |