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Abstract Part Qf Synthetic part. Knoevenagel condensation of 1chloro3,4dihydronaphthalene2carboxaldehyde (1) with ethy1 cyanoacetate and/ or 2cyanomethy1benzothiazole in the presence of piperidine afforded the corresponding sunsaturated nitrile derivatives (2a,b) respectively. When compound 2a was refluxed with hydrazine hydrate and/or phenyl hydrazine in ethanol afforded the corresponding hydrazone derivatives (5a,b). Heating of compound 5a with phenyl isothiocyanate in dioxane gave the corresponding phenylthiourea derivative (10). In addition, it has been found that; thiazolidin4one derivative (12) was obtained via the reaction of compound (10) with chloroacetic acid and anhydrous sodium acetate in glacial acetic acid. Condensation of compound 12 with pchlorobenzaldehyde in the presence of glacial acetic acid and freshly fused sodium acetate yielded the corresponding 5benzylidene thiazolidine4one derivative (13). Moreover, condensation of compound 5a with aromatic aldehydes in ethanol in the presence of catalytic amount of piperidine afforded the corresponding azomethine derivatives (14a,b).When compound 1 refluxed with diaminopyrazole derivatives (31) in dry mixture of DMFpyridine (1:1), furnished exclusively and in reasonable good yield product which could be formulated as 3arylazo6,7dihyro1,4,11ctriazacyclopenta[c]phenanthren2ylamine derivatives (32ad). Part (Np : (BApplication part. Studying the biological activity for these different compounds as antitumer and antibacterial . |