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العنوان
Synthesis of some new heterocyclic compounds containing sulphur and nitrogen of biological interest /
المؤلف
Khalifa, Wesam Farouk Mohammed.
هيئة الاعداد
باحث / Wesam Farouk Mohammed Khalifa
مشرف / Ahmed Ali Hamed Fadda
مشرف / Samir Bahgat Bondock
مشرف / Mohamed Mostafa El­-Ashery
الموضوع
Heterocyclic compounds. Aromaticity (Chemistry). Heterocyclic chemistry.
تاريخ النشر
2005.
عدد الصفحات
149 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
1/1/2005
مكان الإجازة
جامعة المنصورة - كلية العلوم - Chemistry Department
الفهرس
Only 14 pages are availabe for public view

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Abstract

Part Qf Synthetic part. Knoevenagel condensation of 1­chloro­3,4­dihydronaphthalene­2­carbox­aldehyde (1) with ethy1 cyanoacetate and/ or 2­cyanomethy1benzothiazole in the presence of piperidine afforded the corresponding sunsaturated nitrile derivatives (2a,b) respectively. When compound 2a was refluxed with hydrazine hydrate and/or phenyl hydrazine in ethanol afforded the corresponding hydrazone derivatives (5a,b). Heating of compound 5a with phenyl isothiocyanate in dioxane gave the corresponding phenylthiourea derivative (10). In addition, it has been found that; thiazolidin­4­one derivative (12) was obtained via the reaction of compound (10) with chloroacetic acid and anhydrous sodium acetate in glacial acetic acid. Condensation of compound 12 with p­chlorobenzaldehyde in the presence of glacial acetic acid and freshly fused sodium acetate yielded the corresponding 5­benzylidene thiazolidine­4­one derivative (13). Moreover, condensation of compound 5a with aromatic aldehydes in ethanol in the presence of catalytic amount of piperidine afforded the corresponding azomethine derivatives (14a,b).When compound 1 refluxed with diaminopyrazole derivatives (31) in dry mixture of DMF­pyridine (1:1), furnished exclusively and in reasonable good yield product which could be formulated as 3­arylazo­6,7­dihyro­1,4,11c­triaza­cyclopenta[c]phenanthren­2­yl­amine derivatives (32a­d). Part (Np : (BApplication part. Studying the biological activity for these different compounds as antitumer and antibacterial .