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Abstract Different immunostimulants were investigated to detect changes in the activity of nonspecific immune response, disease resistance against infection with A.hyDROPhila and growth performance of Nile tilapia O.nililoticus. In this experiment, O.nililoticus(28.12(R+(B5) fed on diets supplemented with levamisole Hcl at a dose of (255 mg/kg diet), gb?s1.3 glucan of S.cerevisae (EcoActiva<U+2122>) at dose of (3.1 g/kg dry diet), Active dried S.cerevisae yeast culture (Biobuds 2X(R*? (Bat a dose of (1g/kg diet), mixture of vitamin E & C, Sod.Selenite, folic acid and lactose (Immunoton(R*? (Bat dose of 1 g / kg diet and immunostimulant free (control) diet for 2weeks at a feeding rate of 30 g of the diet / kg biomass / day. The obtained results were as follow, addition of levamisole Hcl to the diet of O.nilioticus enhances both cellular and humoral immune responses and increases resistance to A.hyDROPhila infection in addition to little growth promoting activity. Addition of gbs1.3 glucan of S.cerevisiae to the diet of O.niloticus significantly enhances both cellular and humoral immune responses and increases resistance to A.hyDROPhila infection although it have a little growth promoting activity. Addition of whole yeast of S.cerevisea to O.niloticus diet significantly enhances growth rate, cellular immune response and increases resistance to A.hyDROPhila infection. Addition of vitamin C& E to O.niloticus diet in a dose which is higher than the requirements needed for growth lead to maximum growth, with little enhancement of immune response and resistance to A.hyDROPhila infection, while higher doses are needed for maximum immunity. |