الفهرس 
Part I: IntroductionOnly 14 pages are availabe for public view
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Abstract
There is an interactive relationship between leukemia and oxidative stress which can be explained by that free radicals and oxidative processes have been implicated in both initiation and promotion of carcinogenesis by destruction of cells and predisposing these cells to malignant changes. Also, at the same time leukemic cells produce larger amounts of ROS than non leukemic cells, as they are under a continual state of oxidative siege. This study was performed on 46 patients with different types of leukemia. The control group consisted of 10 apparently healthy subjects. The study included the measurement of leukocytes? H2O2 concentration, lipid peroxidation, serum total antioxidant activity, plasma ascorbic acid and dehydroascorbic acid concentrations, blood reduced glutathione concentration, hemolysate G6PD activity, blood catalase activity, serum SOD activity, and serum anti dsDNA concentration. Leukemic patients showed a significant increase in leukocytes H2O2 and serum MDA concentration either before or after treatment. Also, they showed decrease in some antioxidants and an increase in others either before or after treatment but the total antioxidant activity and serum anti dsDNA concentration showed a significant increase in all leukemic patients either before or after treatment. We can conclude that, leukemic patients produce larger amounts of ROS than non leukemic cells. Also, the increase in antioxidants activity in leukemic patients is not high enough to counteract the harmful effects of free radicals. This case becomes worse after administration of chemotherapy which causes an increase in the amount of free radicals. Also, it can be concluded that anti dsDNA may be one of the mechanisms that cause DNA damage and double strand breaks in leukemic patients, which happened independently of the course of treatment of these patients.