الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
p53 mutations were present infrequently in de novo acute leukemia. Higher incidence of p53 mutations were present in aggressive and relapsed leukemia. ALL was associated with higher incidence of p53 mutations than AML The p53 mutation-bearing patients did not differ in their clinical and laboratory data from those without mutations. Flow cytometry assay and PCR-SSCP techniques provide an excellant correlation with sequencing analysis but they must be confirmed by sequencing. Mutations of exon 8 were found in high frequency in relapsed acute leukemia (ALL and AML). Mutations of exon5 were found in acute leukemia patients with poor response to chemotherapy. Mutations of exon 6 were found in patients with poor response to chemotherapy and in relapsed ALL. Mutations of exon 7 were found in relapsed ALL. Mutations of p53 usually affect both alleles with positive (LOH). Large-scale study is necessary to elucidate definite correlation between different exon mutations, pathogenesis and prognosis of acute leukemia.