الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
OBJECTIVES: To evaluate the role of malondialdehyde in the development of preeclampsia, in addition to assay transferrin concentration as non enzymatic antioxidant and study the relation of these changes to the clinical status and the degree of preeclampsia. DESIGN: This work was conducted on 75 pregnant women mild preeclamptic group (25 cases) and severe preeclamptic group (25 cases) in addition to control group (25 cases). The patients were selected serially from follow up outpatient and inpatient clinics of Obstetrics and Gynecology department, Mansoura University Hospital. METHODS: All cases and control were subjected to history taking, clinical examination, CBC, liver function tests, serum creatinine lipogram, Protein in urine, estimation of lipid peroxide metabolite and estimation of transferrin. Results are expressed as mean and standard deviation. MAIN OUTCOME MEASURES: significant increase (P1 < 0.05, P2 < 0.05) in serum MDA in preeclamptic groups versus control group and significant decrease (P1 < 0.05, P2 < 0.05) in serum transferrin in preeclamptic groups versus control group CONCLUSION: Lipid peroxidation degradation product, malondialdehyde, is increased significantly in mild and severe preeclamptic groups; lipid peroxidation may be an important factor in the pathogenesis of preeclampsia by causing endothelial dysfunction and transferrin concentration is decreased significantly in mild and severe preeclamptic groups this may be consequent to oxidative stress. OBJECTIVES: To evaluate the role of malondialdehyde in the development of preeclampsia, in addition to assay transferrin concentration as non enzymatic antioxidant and study the relation of these changes to the clinical status and the degree of preeclampsia. DESIGN: This work was conducted on 75 pregnant women mild preeclamptic group (25 cases) and severe preeclamptic group (25 cases) in addition to control group (25 cases). The patients were selected serially from follow up outpatient and inpatient clinics of Obstetrics and Gynecology department, Mansoura University Hospital. METHODS: All cases and control were subjected to history taking, clinical examination, CBC, liver function tests, serum creatinine lipogram, Protein in urine, estimation of lipid peroxide metabolite and estimation of transferrin. Results are expressed as mean and standard deviation. MAIN OUTCOME MEASURES: significant increase (P1 < 0.05, P2 < 0.05) in serum MDA in preeclamptic groups versus control group and significant decrease (P1 < 0.05, P2 < 0.05) in serum transferrin in preeclamptic groups versus control group CONCLUSION: Lipid peroxidation degradation product, malondialdehyde, is increased significantly in mild and severe preeclamptic groups; lipid peroxidation may be an important factor in the pathogenesis of preeclampsia by causing endothelial dysfunction and transferrin concentration is decreased significantly in mild and severe preeclamptic groups this may be consequent to oxidative stress.