الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acute renal failure is a well known complication and dreadful consequences of burns as it may be lead to increase of mortality rate that may approaches 80% in moderate - severe burns. However, with the recent advances in systemic care of burn patients and better understanding of the exact pathogenic pathways of renal failure and other system affection, patient survival could be made possible. ARF was found to complicate around 40% of burn patients admitted to hospitals and it was found to be related to the size and depth of burn and to extensive fluid loss, muscle damage and acute circulatory compromise as well as, the use of nephrotoxic agents. The development of septicemia after burn can trigger a series of inflammatory reactions and mediators that can lead to multiple organ dysfunction as well as renal damage. These data were found in this study: the larger size of burn and the more frequent of septicemia, the more the prevalence of ARF. In our work, the incidence of ARF was 22.5% and the incidence of septicemia was 47.5% and only 47.5% of patients with septicemia had developed ARF. The correlation between the enhanced oxidative pathway and occurrence of ARF was found significant in this work denoting the importance of anti-oxidant in lessening burn injury and prevention of renal damage in burn. Assessment of renal function in burn should start from day of admission, including glomerular and tubular function tests. Early detection of ARF should be carried out as has been proved in this work. Future therapeutic strategies, that allow a better chance for survival of burn patients who develop ARF, should be applied. The newly introduced dialytic technique as slow continuous arteio-venous and veno-venous hemodiafiltration can help to offer recovery for patients with cardiovascular compromise and patient with hypotension. In conclusion, minimizing the renal damage in burn depend on integrated effort of early and rapid resuscitation after burn injury and early diagnosis of renal affection, as well as the use of the above new dialytic procedure to achieve optimum homeostasis for better patient outcome and survival.