الفهرس 
introductionOnly 14 pages are availabe for public view
 |  | from | 230 |  |  |
| | | from | 230 | | |
Abstract
Blood pictures: There was statistically significant reduction of HB level, RBCs and platelet count in patients group (group I), subgroup IA and subgroup IB in comparison to the control group. However, there is no significant difference between subgroup IA and subgroup IB except for platelet count. Bone marrow aspiration was done for 72 patients (group I) and revealed, hypocellular bone marrow in 3 patients (4.1%), normocellular bone marrow in 63 patients (87.5%) and hypercellular bone marrow in 6 patients (8.3%), with no statistically significant difference between subgroup IA and subgroup IB. Platelet aggregation tests were significantly reduced in group I, subgroups IA & IB in comparison to control groups, also there was significant reduction in subgroup IA in comparison to subgroup IB. TPO level was significantly lower in group I (130.679 pg/ml), in subgroup IA (10177.5 ng/ml) and in subgroup IB (160.270.3 pg/ml) in comparison to the control group (225.536 pg/ml) and also it is significantly lower in subgroup IA in comparison to subgroup IB. Patients with bleeding tendencies have significant lower platelet aggregation test, platelet count and serum TPO level in comparison to the patients without bleeding tendencies. TPO has statistically significant positive correlation with both platelet count and aggregation tests. Splenic size has significant negative correlation with platelet count but no correlation with platelet aggregation tests. There is no significant difference of platelet count, platelet aggregation test, and TPO level according to the aetiology of liver cirrhosis. ” Cirrhotic patients have lower serum TPO levels, lower platelet count and impaired platelet aggregation in comparison to healthy control subjects. ” Cirrhotic patients with thrombocytopenia have lower serum TPO levels and impaired platelet aggregation in comparison to cirrhotic patients with normal platelet count. ” Splenomegaly has a possible pathomechanism of thrombocytopenia specially in patients with child class A. ” Inadequate TPO production may attribute to thrombocytopenia specially in patients with child class B and C. ” Hypocellular bone marrow is not a common finding in patients with liver cirrhosis i.e. it is not directly responsible for thrombocytopenia observed in patients with liver cirrhosis. ” Serum TPO level platelet count and platelet function are inversely related to the severity of liver disease but not to the aetiology of liver disease. ” Cirrhotic patients with bleeding tendency showed marked thrombocytopenia and lower TPO serum level in comparison to patient without bleeding tendency.