الفهرس 
Introduction and aim of the work
Hepatitis c virusOnly 14 pages are availabe for public view
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Abstract
This study was performed on 50 patients with chronic hepatitis C. Our patients were 38 males and 12 females. All patients were subjected to thorough history and clinical examination. Serum samples and liver biopsies were taken from each patient. Many laboratory tests were preformed on the serum samples including anti-HCV antibodies, HBsAg, PCR in serum for . detection of HCV and Liver functions tests. Part of the liver biopsy was fixed in formallin and parffin embedded. Then, the slides were stained with H&E, Masson trichome, Gordon and Sweets, Orcien stain and periodic acid shiff stains .. In all the specimens, ~e 60nfinned the diagnosis of chronic hepatits by the presence of one or more of the following items: portal inflammation, interface hepatitis, hepatocyte necrosis, acinar changes and architecular changes. We tried to study the specific histopathological criteria suggestive of HCV infection. We found that lymph follicle, bile duct lesion and steatosis were useful pathological criteria for diagnosis ofHCV infection. In this study, we used Ishak’s system for grading and staging ofliver biopsies. This system, in spite of having some pitfalls, was the best scoring system. In this study, we found that the level of liver enzymes didn’t correlate with the grade or stage of liver disease. A highly significant relation was found between the degree of activity and histopathological criteria of HCV (lymph follicle, bile duct lesion, sinusoidal lymphocytosis and multinucleation), We could also detect significant relation between HCV RNA in liver tissue and both the degree of activity and the stage of liver disease. In contrast, no significant relation was