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Abstract Juvenile rheumatoid arthritis (JRA) is a well recognized chronic inflammatory condition in children. Many immunologic Abnormalities have been found in children with all forms of chronic arthritis, but as yet none of the known immunologic abnormalities explain the pathogenesis of this disease. Most of the works attempting to explain this pathogenesis is focused on the immune system with the assumption that it must be an autoimmune etiology. If a serologic immune mechanism underlies the onset orpersistence of synovitis of JRA, the complement system will be Activated Previous studies reported discrepant results concerning complement levels and there is no informative data relating complement levels and JRA. In this study, it was assumed that there is a diagnostic and prognostic significance concerning the complement levels namely C3 and C4 with the severity, duration, clinical types of onset and the medical treatment of the disease. |