الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Primary nephrotic syndrome is the most prevalent glomerular injury as it account for 90% of childhood nephrosis. Minimal change lesion represents more than 85% of nephrotic cases due to primary glomerular disease with peak incidence between the age of2 and 6 years. Nephrotic syndrome is still of obscured pathogenesis, although attention have been directed to the role of immune system in pathogenesis of the disease. The role of T -lymphocytes dysfunction was consedered as a cause. The present study was carried out to clarify the role of IL-8 in pathogenesis of PNS. This study was carried out from the period of septamber 1997 to June 1998, where 17 patients were included during disease activity, 17 patients were included during remission and 10 healthy children of matched age and sex were included as a control group. All patients during disease activity and remission were selected from patients either admitted to Pediatric Department of Mansoura University Hospital, or have been followed up in the Out Patients Clinic of Pediatric Nephrology Unite. They all subjected to estimation of serum IL-8 level and its prodaction in supernatant from cultured lvmnhocvtes.