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Abstract This work was carried out on children and adolescents attending the outpatient clinic of Pediatric department and Pediatric Endocrinology and Diabetes unit-Mansoura University Hospitals. The work comprised 35 obese subjects and 11 non obese of matched age, sex and pubertal stage. Subjects were subjected to: 1. Through history and clinical examination and investigation to exclude any disease. 2. Anthropometeric measurements (weight, height, sitting height and subischiallength) and SD score was calculated for each. 3. X-ray left hand for bone age.• 4. Basal blood sample after over neight fast for basal insulin, fasting blood glucose, total cholesterol, LDL-C, HDL-C, T.G, Apo A, and Apo B. 5. OGTT was done after over neight fast and insulin determination was done at basal level, 60 and 120 minute ofOGTT. 6. IRI was calculated from basal insulin and basal glucose according to Matteluews et al. (1985). The results of the study showed that: 1. Blood glucose level studies during OGTT showed that fasting blood glucose was lower in obese compared to non obese and blood glucose level was higher at 60 and 90 min. of OGTT in obese compared to non obese. 2. Insulin level was found to be higher in obese at basal level and during different phases ofOGTT. |