الفهرس 
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Abstract
The pathogenesis of chronic type B hepatitis is generally believed to be mediated by cellular immunity of the host (Thomas et aI, 1982), but details of the ellular immune response are, as yet, unclear. Since the advent of monoclonal antibodies, which can characterize mononuclear cell subpopulations as well as their subsets, progress in studying cellular immunity has become much quicker. It is well-known that immune responses are controlled by the balance of helper id supressor T-cell activity (Reinherz and Schlossman, 1980). Because the results from peripheral blood were controversial, in situ analysis of mononuclear cell infiltrates in the liver has attracted much attension recently. This study was conducted on 20 children chosen from those attending the Pediatric Gastroenterology Unit, Pediatric Department, Mansoura University Hospital. They were classified histopathologically into 2 groups: Group I : Ten patients with Chronic active hepatites-B., they were 7 males and 3 females with their ages ranged from 2-12.5 years. Group II : Ten patients with chronic persistent hepatitis-B, they were 5 males and 5 females with their ages raged between 2-15 years. Control group : This group comprised 10 healthy children without any apparent evidence of liver disease or organic diseases of immunological basis. Apatients and controls were subjected to the following: 1- Careful clinical examination. 2- Routine tests: (stool analysis - urine analysis -complete blood picture) 3-Liver function tests (AST, ALT, Alk. Phospho , prothrombine activity). 4- Serum proteins (total serum proteins - serum albumin -serum globulins).