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العنوان
Value of glycosylated hemoglobin in uremic patients /
الناشر
Eman Mohamed Mekia,
المؤلف
Mekia, Eman Mohamed.
هيئة الاعداد
باحث / Eman Mohamed Mekia
مشرف / Nabil Ismail Lymon
مشرف / Osama Saad Salama
باحث / Eman Mohamed Mekia
الموضوع
Glycosylated hemoglobin-- Uremia.
تاريخ النشر
1993.
عدد الصفحات
119 p.,
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب
تاريخ الإجازة
1/1/1993
مكان الإجازة
جامعة المنصورة - كلية الطب - DEPARTMENT OF GENERAL MEDICINE
الفهرس
Only 14 pages are availabe for public view

from 133

from 133

Abstract

Glycosylated Hb is a model of non enzymatic post-synthetic protein modification proportionate with blood glucose level. Its role in uremia is however unclear. Moreover, the effect of uremia on Hb glycosylation was shown to be more complicated. Therefore, the aim of this study was to clarify the reflection of uremia on glycosylated Hb level. The material of this study included 30 patients with CRF and CRF diabetics besides 5 non uremic diabetics and 10 healthy controls. Glycosylated Hb was assayed in all subjects and was reported after in uremic cases. We concluded that the level of glycosylated Hb has been significantly reduced in CRF which could be due to shortened red cell survival, while in CRF diabetics it was higher due to their high blood glucose. Moreover, hemodialysis resulted in elevation of glycosylated Hb due to the improved red cells survival. A positive correlation has been revealed between glycosylated lib and serum creatinine, a finding that may aid in the diagnosis and follow up of CRF particularly in doubtful cases.