الفهرس 
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Abstract
This study is divided into 2 parts : Clinical part: included 30 patients with H.C.C.; 25 males with mean age 55.7±11.2 years and 5 females with mean age 44±6.5 years. Every patient was subjected to: Clinical assessment, routine lab. Assessment, liver function tests, serological markers of viral hepatitis, serum AFP, aflatoxin and pesticide determination, abdominal U.S., and percutaneous needle liver biopsy. II. Experimental part: included induction of mutation by treatment with O.O.T. and aldrin applied, in different concentrations at variable incubation periods, on E.coli o J< [8-], 78 80 Our study revealed that aflatoxin ve group has been found to predict a rather younger age. It lacked the famous predominance of male sex and included the housewives as a major sector of its cases. Abdominal pain was a common feature of a latent aflatoxin sharing in the development of H.C.C. The symptoms and signs of chronic liver disease like jaundice, ascites, and bleeding tendency had developed more in aflatoxive group, in contrast to aflatoxin -ve group. instead of a larger liver size. Tenderness and nodularity of the liver had been found to be features of aflatoxin ve group. This clinical situation associating aflatoxin ve group was accompanied with a high positivity of hepatitis markers versus aflatoxin -ve group with a predominant feature of hepatitis B surface antigenemia with its known more worse hepatic condition. Laboratory data hadn’t add much peculiarities to aflatoxin ve group rather than the traditional famous marker of a more advanced liver disease; prolonged prothrombin time.