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Abstract Bleeding from oesophageal varices is a major cause of morbidity and mortality in cirrhotic patients (Graham & Smith, 1981) as well as in patients with hepatosplenic schistosomiasis (Cordeiro, 1990). Once a ’ patient had bled from varices, the risk of rebleeding is 70% or more (De-DombaletaL, 1986). 4 Endoscopic sclerotherapy is widely used for treatment of haemorrhage from rupture oesopahgeal varices, however before variceal oblitration, sclerotherpay treated patients may experience a rebleeding in a rate of 50%. In the last few years some drugs have been widely used in patient with liver cirrhosis to prevent recurrent bleeding. The aim of the present study was to compare sclerotherapy alone versus sclerotherapy and long acting ACEinhibitor lisinopril (zestril) for long term management of variceal bleeding and how portal hemodynamic is influenced by eradication of oesophageal varices. The study was conducted on 76 patients with first attack bleeding oesophageal varices admitted to the unite of Haematemesis and Melena, Mansoura Emergency Hospital. They were devided into 2 groups: |