الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 204 |  |  |
| | | from | 204 | | |
Abstract
We performed a follow-up study in 47 patients with end stage renal disease (ESRD) using as a reference the blood donated by 73 healthy individuals. our study included lymphocyte proliferation to mitogens, spontaneous transformation, the production of interleukin-2, the activities of both natural killer cells (NK), cell mediating anti- body dependent cellular cytotoxicity (ADCC) and the effects of biolo- gical modifiers on these activities, we correlated the results with rejection episodes and the mode of osuppressive therapy used in the patients. The present study showed that patients with ESRD had a signifi- cant decrease in lymphocyte proliferation to concanavalin A (ConA), as well as IL-2 production by those stimulated cells compared to normal blood donors. They had also a significant decrease in NK activity and normal ADCC compared with those of normal blood donors. Biological modifiers, corrected the suppressed NK activity in those patients. Patients with ESRD due to type 1 diabetes showed a significant decrease in their IL-2 production and NK activity compared with other atiological groups of ESRD. Patients with ESRD due to essential hypertension showed a significant decrease in lymphocyte proliferation to phytohemagglutinin (PHA) as well as a decrease in IL-2 production from peripheral blood lymphocytes compared with other atiological groups of ESRD.