الفهرس 
Summary of the oreginal workOnly 14 pages are availabe for public view
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Abstract
Preparation of two chloroindole starting materials I, II, VilsmeierHaak formylation of I and II to gave the two starting formyl indole compounds III and IV. The starting formyl compounds III and IV were reacted with hydrazine hydrate to give V and VI compounds, , with phenyl hydrazine to give VII and VIII compounds, with hydroxyl amine hydrochloride to give IX and X, with acetophenone and hydroxyl acetophenone to give XVI and XVII and XVIII. Bromination of compounds XVI and XVIII gives dibromo derivatives XXV and XXVIII respectively which condensed with 1naphtyl amine and 2naphthol to give benzoindole compounds XXVII and XXX respectively. Formyl derivatives III and IV reacted with the active methylene derivatives; malononitrile, ethyl cyanoacetate and diethyl malonate. Another reactions with active methylene and urea or thiourea in one flask which give products used to synthesize biologically active compounds e.g. thiazolo (2,3a) pyrimidine derivatives LXIV and LXVII. Acetylation of the starting materials I and II give the Nacetyl derivatives LXVIII and LXIX respectively. Nacetyl derivative LXIX fused with sodium hydroxide to give the hydroxyl acetyl compound LXX which used to synthesize the oxazolo (5,4,3HI) indole derivative LXXVI. Nitration of the starting materials I and II give the nitroindole derivatives LXXVII and LXXVIII. Reduction of the nitroindole derivative LXXVIII give the amino indole derivative LXXIX which was reacted with III and IV and 3nitrobenzaldehyde to synthesize the Schiff,s bases LXXX, LXXXI and LXXXII. Some of synthesized chloroindole derivatives have been tested for microbial activity against gram negative, positive bacterium and two Fungi.